Author

D. Sansom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Kennedy· 2 shared C. Hinze· 2 shared S. Dovedi· 2 shared B. Bilanges· 1 shared B. L. Jamison· 1 shared B. Vanhaesebroeck· 1 shared C. J. Courreges· 1 shared C. J. Wang· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

A. Kennedy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction

M. A. Robinson, A. Kennedy, C. T. Orozco, H.-C. Chen, E. A. Waters, D. Giovacchini, K. Yeung, L. Filer, C. Hinze, C. Lloyd, S. Dovedi, D. Sansom

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.

bioRxiv · Apr 19, 2024 · PreprintImmunology

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

C. J. Courreges, E. C. Davenport, B. Bilanges, E. Rebollo-Gomez, J. Hukelmann, P. Schoenfelder, J. R. Edgar, D. Sansom, C. Scudamore, R. Roychoudhuri, O. A. Garden, B. Vanhaesebroeck, K. Okkenhaug

This study shows that VPS34 deficiency in regulatory T cells causes a fatal lymphoproliferative disorder by impairing metabolic and functional processes, despite normal development and in vitro suppression.

bioRxiv · Jan 8, 2024Immunology

An IL-2 mutein increases IL-10 and CTLA-4-dependent suppression of dendritic cells by regulatory T cells

B. L. Jamison, M. Lawrance, C. J. Wang, H. A. DeBerg, D. Sansom, M. A. Gavin, L. S. K. Walker, D. J. Campbell

The paper shows an IL-2 mutein expands regulatory T cells that enhance IL-10 and CTLA-4 to suppress dendritic cells, reducing autoimmunity in NOD mice.

bioRxiv · Dec 1, 2023 · PreprintImmunology

CTLA-4 regulates PD-L1-PD-1 interactions via transendocytosis of CD80

A. Kennedy, M. Robinson, C. Hinze, E. Waters, C. Williams, N. Halliday, S. Dovedi, D. Sansom

The paper investigates how CTLA-4 regulates PD-L1-PD-1 interactions through CD80 transendocytosis, showing that CD80 removal enables PD-L1 recovery and that CTLA-4's cytoplasmic domain is essential for this process.

bioRxiv · Mar 28, 2022 · PreprintImmunology