Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survival
L. Cottone, E. S. Hookway, A. Cribbs, G. Wells, P. Lombard, L. Ligammari, A. Tumber, R. Tirabosco, F. Amary, T. Szommer, C. Johannson, P. E. Brennan, N. Pillay, U. Oppermann, A. M. Flanagan
This study shows that inhibiting H3K27 demethylases reduces TBXT expression and kills chordoma cells by altering epigenetic marks and gene expression.
bioRxiv · Oct 1, 2018 · PreprintCancer Biology