Author

P. E. Brennan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Organism:human· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:statistical model· 1

Frequent Co-Authors

O. Fedorov· 3 shared S. Knapp· 3 shared A. Chaikuad· 2 shared D. Heidenreich· 2 shared G. F. Ruda· 2 shared T. Moreira· 2 shared A. Aimon· 1 shared A. Bradley· 1 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

O. Fedorov

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2

W. J. Bradshaw, E. C. Kennedy, T. Moreira, L. A. Smith, R. Chalk, V. L. Katis, J. L. Benesch, P. E. Brennan, E. J. Murphy, O. Gileadi

The paper determines structures of SHIP1 and SHIP2 phosphatase and C2 domains, showing the C2 domain modulates phosphatase activity more in SHIP2 than SHIP1, providing insights for drug development.

bioRxiv · Jul 31, 2023Biochemistry

The structural basis of fatty acid elongation by the ELOVL elongases

L. Nie, A. C. Pike, T. C. Pascoa, S. R. Bushell, A. Quigley, G. F. Ruda, A. Chu, V. Cole, D. Speedman, T. Moreira, L. Shrestha, S. M. Mukhopadhyay, N. A. Burgess-Brown, J. D. Love, P. E. Brennan, E. P. Carpenter

The paper reports the structure of the human ELOVL7 elongase, revealing its catalytic mechanism and substrate-binding sites, with implications for inhibiting VLCFA accumulation in diseases.

bioRxiv · Nov 11, 2020Biochemistry

A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL) YEATS domain

D. Heidenreich, M. Moustakim, J. Schmidt, D. Merk, P. E. Brennan, O. Fedorov, A. Chaikuad, S. Knapp

The paper identifies inhibitory fragments targeting the ENL YEATS domain using crystallography, providing starting points for chemical probe development.

bioRxiv · Nov 8, 2018Biochemistry

Rapid covalent-probe discovery by electrophile fragment screening

e. resnick, A. Bradley, J. Gan, A. Douangamath, T. Krojer, R. Sethi, A. Aimon, G. Amitai, D. Belini, J. Bennett, M. Fairhead, O. Fedorov, P. P. Geurink, J. Guo, A. Plotnikov, , N. London

This study develops a method for discovering covalent probes using electrophile fragment screening and identifies selective inhibitors for OTUB2 and NUDT7.

bioRxiv · Oct 14, 2018Biochemistry

A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling

Q. Wu, D. Heidenreich, S. Zhou, S. Ackloo, G. Deblois, S. Duan, K. Nakka, J. Dilworth, M. Lupien, P. E. Brennan, C. H. Arrowsmith, S. Mueller, O. Fedorov, P. Filippakopoulos, S. Knapp

The paper presents a set of 25 chemical probes targeting human bromodomains and demonstrates their utility in studying muscle cell differentiation and triple negative breast cancer.

bioRxiv · Aug 14, 2018Cell Biology

Halogen-aromatic π-interactions modulate inhibitor residence time

C. Heroven, V. Georgi, G. K. Ganotra, P. E. Brennan, F. Wolfreys, R. C. Wade, A. E. Fernandez-Montalvan, A. Chaikuad, S. Knapp

The paper shows that halogen-aromatic π-interactions increase inhibitor residence time in kinase-inhibitor complexes, providing a strategy to improve drug efficacy and selectivity.

bioRxiv · Jan 29, 2018Biophysics