Author

A. M. Flanagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Assay:DNA methylation· 3 Research Focus:variant calling· 3 Assay:whole-genome sequencing· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2

Frequent Co-Authors

C. D. Steele· 2 shared F. Amary· 2 shared I. Cortes-Ciriano· 2 shared N. Pillay· 2 shared R. Tirabosco· 2 shared A. Abbasi· 1 shared A. Al-Ibraheemi· 1 shared A. C. Hirbe· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

C. D. Steele

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mechanisms underpinning osteosarcoma genome complexity and evolution

J. Espejo Valle-Inclan, S. De Noon, K. Trevers, H. Elrick, M. Tanguy, T. Butters, F. Muyas, F. Amary, R. Tirabosco, A. Giess, A. Sosinky, G. Elgar, A. M. Flanagan, I. Cortes-Ciriano

This study identifies chromothripsis and a novel LTA chromothripsis mechanism driving genome complexity and evolution in osteosarcoma, with prognostic implications for high-grade tumors.

bioRxiv · Dec 29, 2023 · PreprintCancer Biology

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

J. E. G. Lawrence, S. Woods, K. Roberts, D. N. Sumanaweera, P. Balogh, A. V. Predeus, P. He, T. Li, K. Polanski, E. Prigmore, E. Tuck, L. Mamanova, D. Zhou, S. Webb, L. Jardine, , S. Teichmann

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

bioRxiv · Dec 20, 2023Bioengineering

Genomic patterns of malignant peripheral nerve sheath tumour (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNA

I. Cortes-Ciriano, C. D. Steele, K. G. Piculell, A. Al-Ibraheemi, V. Eulo, M. M. Bui, A. Chatzipli, B. C. Dickson, D. C. Borcherding, A. Feber, A. Galor, J. Hart, K. B. Jones, J. T. Jordan, R. H. Kim, , D. T. Miller

This study identifies genomic patterns in MPNST evolution linked to clinical outcomes and shows these patterns are detectable in cell-free DNA.

bioRxiv · May 3, 2022 · PreprintCancer Biology

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

L. Cottone, L. Ligammari, H. J. Knowles, H.-M. Lee, S. Henderson, S. Bianco, C. Davies, S. Strauss, F. Amary, A. P. Leite, R. Tirabosco, K. Haendler, J. L. Schultze, J. Herrero, P. ODonnell, , A. M. Flanagan

This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.

bioRxiv · Dec 27, 2021Cancer Biology

Signatures of copy number alterations in human cancer

C. D. Steele, A. Abbasi, A. S. M. Islam, A. Khandekar, K. Haase, S. Hames, M. Tarabichi, T. Lesluyes, A. M. Flanagan, F. Mertens, P. Van Loo, L. B. Alexandrov, N. Pillay

This paper identifies 19 copy number signatures in 9,873 cancers, explaining 93% of TCGA samples, and reveals diverse mechanisms underlying copy number alterations in human cancer.

bioRxiv · Apr 30, 2021Cancer Biology