Author

L. Cottone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

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Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. M. Flanagan· 2 shared F. Amary· 2 shared L. Ligammari· 2 shared R. Tirabosco· 2 shared A. Cribbs· 1 shared A. E. Grigoriadis· 1 shared A. P. Leite· 1 shared A. Tumber· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. M. Flanagan

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2 papers

Recent·Most cited

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

L. Cottone, L. Ligammari, H. J. Knowles, H.-M. Lee, S. Henderson, S. Bianco, C. Davies, S. Strauss, F. Amary, A. P. Leite, R. Tirabosco, K. Haendler, J. L. Schultze, J. Herrero, P. ODonnell, , A. M. Flanagan

This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.

bioRxiv · Dec 27, 2021Cancer Biology

Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survival

L. Cottone, E. S. Hookway, A. Cribbs, G. Wells, P. Lombard, L. Ligammari, A. Tumber, R. Tirabosco, F. Amary, T. Szommer, C. Johannson, P. E. Brennan, N. Pillay, U. Oppermann, A. M. Flanagan

This study shows that inhibiting H3K27 demethylases reduces TBXT expression and kills chordoma cells by altering epigenetic marks and gene expression.

bioRxiv · Oct 1, 2018 · PreprintCancer Biology