Author

C. K. Boyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

J. Zhang· 3 shared Y. Wang· 3 shared K. E. Rohli· 2 shared S. B. Stephens· 2 shared S. C. Bearrows· 2 shared A. PARCHURE· 1 shared B. R. Ramazanov· 1 shared C. J. Bauchle· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

J. Zhang

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3 papers

Recent·Most cited

Synchronized proinsulin trafficking reveals delayed Golgi export accompanies beta-cell secretory dysfunction in a rodent model of hyperglycemia

C. K. Boyer, J. Zhang, Y. Wang, S. B. Stephens

This study uses a rodent model of hyperglycemia to show that proinsulin trafficking is delayed at the Golgi, contributing to beta-cell secretory dysfunction in Type 2 diabetes.

bioRxiv · Oct 31, 2022 · PreprintCell Biology

Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules

A. PARCHURE, M. Tian, C. K. Boyer, S. C. Bearrows, K. E. Rohli, J. Zhang, B. R. Ramazanov, Y. Wang, S. Stephens, J. von Blume

The paper shows that chromogranin proteins undergo liquid-liquid phase separation at the TGN to recruit and sort proinsulin and other cargo molecules into secretory granules, independent of specific sequence elements.

bioRxiv · Dec 22, 2021Cell Biology

Nutrient metabolism regulates insulin granule formation in the pancreatic islet β-cell via ER redox homeostasis

K. E. Rohli, C. K. Boyer, S. C. Bearrows, M. R. Moyer, W. S. Elison, C. J. Bauchle, S. E. Blom, C.-L. Yu, M. R. Pope, J. Zhang, Y. Wang, S. B. Stephens

This study shows that nutrient metabolism and ER redox homeostasis regulate insulin granule formation in pancreatic β-cells, linking glucose metabolism to proinsulin export and T2D pathogenesis.

bioRxiv · Sep 22, 2021 · PreprintCell Biology