Anti-psychotic drugs act synergistically in combination with antifungal drugs to inhibit drug-resistant Cryptococcus and Candida species
Magali Ayala, Alifia Jakamartana, Rodrigo Mamede Dos Santos Costa, Joseph M. Bednarek, Christian T. Moreau, C. K. Cheung, Jessica C. S. Brown
The paper identifies synergistic combinations of anti-psychotic and antifungal drugs to treat drug-resistant fungal infections and suggests chlorpromazine targets lipid homeostasis.
bioRxiv · Jan 2, 2026 · PreprintMicrobiology