Author

E. D. Crawford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:metagenomics· 4 Approach:deep learning· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:variant calling· 2

Frequent Co-Authors

C. Langelier· 4 shared R. Sit· 4 shared A. Lyden· 3 shared J. Quan· 3 shared M. Tan· 3 shared S. Caldera· 3 shared A. McGeever· 2 shared B. Dimitrov· 2 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMicrobiology

C. Langelier

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Author profile →

5 papers

Recent·Most cited

Designing and implementing programmable depletion in sequencing libraries with DASHit

D. Dynerman, A. Lyden, J. Quan, S. Caldera, A. McGeever, B. Dimitrov, R. King, G. Cirola, M. Tan, R. Sit, M. van den Berge, H. A. M. Kerstjens, A. Faiz, S. Christenson, C. Langelier, , E. D. Crawford

The paper introduces DASHit, a software tool that designs CRISPR-based depletion targets to reduce high-abundance sequences in sequencing libraries, demonstrating its effectiveness across three species.

bioRxiv · Jan 12, 2020 · PreprintMicrobiology

Investigating Transfusion-Related Sepsis using Culture-Independent Metagenomic Sequencing

E. D. Crawford, J. Kamm, S. Miller, L. Li, S. Caldera, A. D. Lyden, D. Yokoe, A. Nichols, N. K. Tran, S. Barnhard, P. M. Conner, A. Nambiar, M. S. Zinter, M. Moayeri, P. Hayakawa Serpa, , C. Langelier

This study uses metagenomic sequencing to identify pathogens in transfusion-related sepsis cases, revealing a novel Acinetobacter species and demonstrating the utility of culture-independent methods.

bioRxiv · Sep 16, 2019Microbiology

Serological and metagenomic interrogation of cerebrospinal fluid implicates enteroviruses in pediatric acute flaccid myelitis

R. D. Schubert, I. Hawes, P. S. Ramachandran, A. Ramesh, E. D. Crawford, J. E. Pak, W. Wu, C. K. Cheung, B. D. O'Donovan, C. M. Tato, A. Lyden, M. Tan, R. Sit, G. Sowa, H. A. Sample, , Ob

This study identifies high levels of enterovirus antibodies in cerebrospinal fluid of children with acute flaccid myelitis compared to controls, suggesting a causal role for non-polio enteroviruses.

bioRxiv · Jun 19, 2019Microbiology

FLASH: A next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

J. Quan, C. Langelier, A. Kuchta, J. Batson, N. Teyssier, A. Lyden, S. Caldera, A. McGeever, B. Dimitrov, R. King, J. Wilheim, M. Murphy, L. Pesce Ares, K. A. Travisano, R. Sit, , E. D. Crawford

FLASH is a CRISPR-based diagnostic method that enhances detection of low-abundance antimicrobial resistance sequences in metagenomic data.

bioRxiv · May 12, 2019Microbiology

Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children

M. S. Zinter, C. C. Dvorak, M. Y. Mayday, K. Iwanaga, N. P. Ly, M. E. McGarry, G. D. Church, L. E. Faricy, C. M. Rowan, J. R. Hume, M. E. Steiner, E. D. Crawford, C. Langelier, K. Kalantar, E. D. Chow, , J. L. DeRisi

This study develops a metagenomic sequencing assay to detect missed pathogens in immunocompromised children, finding increased sensitivity for identifying potential pathogens in lung samples.

bioRxiv · Mar 29, 2018Microbiology