Author

A. Lyden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metagenomics· 2 Organism:mouse· 2 Research Focus:variant calling· 2

Frequent Co-Authors

E. D. Crawford· 3 shared R. Sit· 3 shared A. McGeever· 2 shared B. Dimitrov· 2 shared C. Langelier· 2 shared J. Quan· 2 shared M. Tan· 2 shared R. King· 2 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

E. D. Crawford

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Designing and implementing programmable depletion in sequencing libraries with DASHit

D. Dynerman, A. Lyden, J. Quan, S. Caldera, A. McGeever, B. Dimitrov, R. King, G. Cirola, M. Tan, R. Sit, M. van den Berge, H. A. M. Kerstjens, A. Faiz, S. Christenson, C. Langelier, , E. D. Crawford

The paper introduces DASHit, a software tool that designs CRISPR-based depletion targets to reduce high-abundance sequences in sequencing libraries, demonstrating its effectiveness across three species.

bioRxiv · Jan 12, 2020 · PreprintMicrobiology

Serological and metagenomic interrogation of cerebrospinal fluid implicates enteroviruses in pediatric acute flaccid myelitis

R. D. Schubert, I. Hawes, P. S. Ramachandran, A. Ramesh, E. D. Crawford, J. E. Pak, W. Wu, C. K. Cheung, B. D. O'Donovan, C. M. Tato, A. Lyden, M. Tan, R. Sit, G. Sowa, H. A. Sample, , Ob

This study identifies high levels of enterovirus antibodies in cerebrospinal fluid of children with acute flaccid myelitis compared to controls, suggesting a causal role for non-polio enteroviruses.

bioRxiv · Jun 19, 2019Microbiology

FLASH: A next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

J. Quan, C. Langelier, A. Kuchta, J. Batson, N. Teyssier, A. Lyden, S. Caldera, A. McGeever, B. Dimitrov, R. King, J. Wilheim, M. Murphy, L. Pesce Ares, K. A. Travisano, R. Sit, , E. D. Crawford

FLASH is a CRISPR-based diagnostic method that enhances detection of low-abundance antimicrobial resistance sequences in metagenomic data.

bioRxiv · May 12, 2019Microbiology

Modulating pathogenesis with Mobile-CRISPRi

O. Rosenberg, J.-X. Qu, N. K. Prasad, J. Peters, M. Looney, M. Yu, A. Lyden, S. Chen, E. Crawford, M. Silvis

The paper demonstrates the use of Mobile-CRISPRi to knock down virulence life-style genes in a murine infection model, showing reduced virulence in mice.

bioRxiv · Apr 25, 2019Microbiology