Sialic acid ligands of CD28 block co-stimulation of T cells
L. J. Edgar, A. J. Thompson, V. F. Vartabedian, C. Kikuchi, J. L. Woehl, J. R. Teijaro, J. C. Paulson
The paper shows sialic acid ligands on T cells and APCs block CD28 co-stimulation, reducing T cell activation and enhancing effector function when sialic acids are removed.
bioRxiv · Feb 22, 2021 · PreprintImmunology