J. C. Paulson

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

Potential pandemic risk of circulating swine H1N2 influenza viruses

The paper assesses the pandemic risk of swine H1N2 influenza viruses by analyzing their transmission potential and immune response in ferrets.

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.

Evolving spike-protein N-glycosylation in SARS-CoV-2 variants

This study compares N-glycan processing in SARS-CoV-2 spike-proteins across variants to understand immune evasion mechanisms.

DeGlyPHER: an ultrasensitive method for analysis of viral spike N-glycoforms

DeGlyPHER is an ultrasensitive method to analyze viral spike N-glycoforms, assessing glycan occupancy and processing from high-mannose to complex forms at each N-glycosylation site.

Coordinated changes in glycosylation regulate the germinal centre through CD22

This study shows that glycan remodeling and CD22 downregulation are essential for proper germinal center function, including plasma cell output and antibody affinity maturation.

Sialic acid ligands of CD28 block co-stimulation of T cells

The paper shows sialic acid ligands on T cells and APCs block CD28 co-stimulation, reducing T cell activation and enhancing effector function when sialic acids are removed.

Visualization of the HIV-1 Env Glycan Shield Across Scales

This study uses cryo-EM, computational modeling, and mass-spectrometry to analyze the HIV-1 Env glycan shield's structure and dynamics, revealing how heterogeneity and interactions affect epitope accessibility and trimer stability.

Saccharomyces cerevisiae Ecm2 Modulates the Catalytic Steps of pre-mRNA Splicing

This study investigates the role of Ecm2 in yeast splicing, showing it modulates catalytic steps and facilitates splice site usage.

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

The paper uses cryo-EM and glycan analysis to study the structure of a full-length SARS-CoV-2 spike protein in a vaccine candidate, revealing its stable prefusion conformation and novel trimer interactions.

Modulation of Siglec-7 Signaling via in situ Created High-affinity cis-Ligands

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

Tolerogenic nanoparticles targeting B and T lymphocytes delay autoimmune arthritis in K/BxN mice

This study combines two nanoparticle approaches to induce antigen-specific tolerance in mice, showing synergy in delaying autoimmune arthritis.

Genetically Encoded, Multivalent Liquid Glycan Array (LiGA)

The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.

Glycoengineering of NK cells with glycan ligands of CD22 and selectins for B-cell lymphoma therapy

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.