J. R. Teijaro

Autoimmunity associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity

The study shows that the PTPN22 1858C>T allele, linked to autoimmunity, enhances anti-viral immunity by improving CD4 T cell responses and CD8-cDC function during LCMV infection.

Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.

This study identifies covalent compounds that inhibit NLRP3 inflammasome assembly by targeting reactive cysteines, suggesting NLRP3 as an electrophile sensor for inflammatory signaling.

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

This study identifies an allosteric cysteine in JAK1 and TYK2, develops inhibitors targeting it, and shows high subtype selectivity with minimal off-target effects.

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

This study engineers SARS-CoV-2 neutralizing antibodies through directed evolution to enhance their potency and reduce viral escape.

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

This study identifies a broadly neutralizing antibody that targets a conserved site on beta-coronavirus spike proteins and provides protection against SARS-CoV-2 infection.

Sialic acid ligands of CD28 block co-stimulation of T cells

The paper shows sialic acid ligands on T cells and APCs block CD28 co-stimulation, reducing T cell activation and enhancing effector function when sialic acids are removed.

Identification of an N-acetylneuraminic acid-presenting bacteria isolated from a healthy human microbiome

The paper identifies an Escherichia coli strain that presents sialic acid on its surface and develops a method to track sialic acid-presenting microbes in complex microbiomes.

TLR9-activated B cells improve their regulatory function by endogenously produced catecholamines

This study shows that TLR9-activated B cells produce catecholamines, enhancing their regulatory function through adrenergic receptor activation and increased IL-10 and co-inhibitory ligand expression.

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

ISG15 drives immune pathology and respiratory failure during viral infection

This study shows that lack of deISGylation during viral infection leads to immune pathology and respiratory failure, with extracellular ISG15 playing a key role in inflammation and disease severity.

Detecting Tumor Specific Antigen-Reactive T cells from Tumor Infiltrating Lymphocytes via Interaction Dependent Fucosyl-biotinylation

This paper introduces FucoID, a method to detect and isolate tumor-specific antigen-reactive T cells from tumor-infiltrating lymphocytes using fucosyl-biotinylation, revealing distinct gene features and functional capabilities.