Synchronized infection identifies early rate-limiting steps in the hepatitis B virus life cycle.
A. Chakraborty, C. Ko, C. Henning, A. Lucko, X. Zhuang, J. M. Wettengel, U. Protzer, J. A. McKeating
This study uses synchronized infection to analyze HBV entry and cccDNA formation, finding that most viral particles enter cells but only a small fraction becomes cccDNA, highlighting a rate-limiting step in infection.
bioRxiv · Apr 5, 2020Microbiology