X. Zhuang

Diverse origins of near-identical antifreeze proteins in unrelated fish lineages provide insights into evolutionary mechanisms of new gene birth and protein sequence convergence

This study investigates the origins of near-identical antifreeze proteins in unrelated fish lineages, revealing distinct evolutionary pathways and mechanisms.

Science Education for the Youth (SEFTY): A Neuroscience Outreach Program for High School Students in Southern Nevada During the COVID-19 Pandemic

The SEFTY program provided neuroscience-based experiential learning to high school students during the pandemic, improving science proficiency by 20.3%.

Cell-type-specific 3D-genome organization and transcription regulation in the brain

The paper investigates 3D-genome organization and transcription regulation in distinct cell types of the mouse brain, finding cell-type-specific nuclear architecture and chromatin compartmentalization correlated with transcriptional activity and MeCP2 regulation.

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

Functional genomics identifies extension of complex N-glycans as a mechanism to evade lysis by natural killer cells

The paper identifies SPPL3 as a gene that enables tumor cells to evade NK cell lysis by altering N-glycan structures, and shows that inhibiting N-glycan maturation restores NK sensitivity.

ABI5-FLZ13 Module Transcriptionally Represses Growth-related Genes to Delay Seed Germination in Response to ABA

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

Circadian regulation of human immunodeficiency virus type 1 replication

This study shows HIV-1 replication is regulated by circadian rhythms through interactions between transcription factors BMAL1, REV-ERB, and ROR, with implications for HIV therapy.

Subscaling of a cytosolic RNA binding protein governs cell size homeostasis in the multiple fission alga Chlamydomonas

This study identifies TNY1, a cytosolic RNA-binding protein, as a key regulator of cell size homeostasis in Chlamydomonas through subscaling, which controls division number and daughter cell size.

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.

This study shows that activating HIF signaling reduces SARS-CoV-2 infection and respiratory symptoms in hamsters by decreasing viral RNA and epithelial damage.

Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant

This paper develops a ferritin-based nanoparticle vaccine targeting the SARS-CoV-2 Omicron variant, showing enhanced immunogenicity compared to a non-nanoparticle version.

Positive and relaxed selective pressures have both strongly influenced the evolution of cryonotothenioid fishes during their radiation in the freezing Southern Ocean

This study examines the genetic changes in cryonotothenioid fishes under cold and hemoglobin loss, finding positive and relaxed selection shaped their evolution.

Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences

The paper quantifies SARS-CoV-2 RNA molecules using smFISH, revealing genomic RNA stability, cell-to-cell replication variability, and slower replication kinetics for the B.1.1.7 variant compared to the Victoria strain.

The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation

This paper identifies the METTL5-TRMT112 complex as the methyltransferase responsible for m6A modification at 18S rRNA, linking it to metabolism and development.

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

This study shows BMAL1 regulates ACE2 expression and SARS-CoV-2 entry in lung epithelial cells, with SR9009 reducing viral replication through circadian mechanisms.

Spatial organization of the transcriptome in individual neurons

This study maps the spatial organization of RNA in individual neurons using MERFISH, revealing distinct transcriptome compositions and sub-dendritic RNA distribution patterns.

The CCCTC-binding factor CTCF represses hepatitis B virus Enhancer I and regulates viral transcription

This study identifies CTCF as a repressor of HBV transcription by binding to Enhancer I and reducing pre-genomic RNA levels.

Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

This study shows that REV-ERB agonists inhibit HIV-1 replication by suppressing its promoter activity in multiple cell types.

Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway

Synchronized infection identifies early rate-limiting steps in the hepatitis B virus life cycle.

This study uses synchronized infection to analyze HBV entry and cccDNA formation, finding that most viral particles enter cells but only a small fraction becomes cccDNA, highlighting a rate-limiting step in infection.

Role of RgsA in oxidative stress resistance in Pseudomonas aeruginosa

This study shows that deletion of RgsA in Pseudomonas aeruginosa reduces growth and oxidative stress resistance in both planktonic and biofilm states.

Arginine-GlcNAcylation of death domain and NleB/SseK proteins is crucial for bacteria pathogenesis by regulating host cell death

This study identifies arginine-GlcNAcylation as a mechanism by which bacterial effectors NleB and SseKs modulate host death receptor signaling to promote pathogenesis.

m6A-binding YTHDF proteins promote stress granule formation by modulating phase separation of stress granule proteins

This study shows that m6A-binding YTHDF proteins facilitate stress granule formation by modulating phase separation through their m6A-binding domain and intrinsically disordered region.

Molecular Identification and Characterization of Two Rubber Dandelion Amalgaviruses

The paper identifies and characterizes two new amalgaviruses in rubber dandelion, proposing new species names based on phylogenetic analysis and RNAseq data.

Multiplexed detection of RNA using MERFISH and branched DNA amplification

This paper introduces a branched DNA amplification method for MERFISH to enhance RNA detection efficiency and performance.

Multiplexed imaging of high density libraries of RNAs with MERFISH and expansion microscopy

This paper combines MERFISH with expansion microscopy to increase RNA measurement density and demonstrates accurate RNA identification in high-abundance libraries.

Exploring the Genetics of Lesion and Nodal Resistance in Pea (Pisum sativum L.) to Sclerotinia sclerotiorum Using Genome-wide Association Studies and RNA-Seq

This study uses GWAS and RNA-Seq to identify genetic differences between lesion and nodal resistance in pea to Sclerotinia sclerotiorum, finding distinct genetic mechanisms for each resistance type.

Analyzing Single Molecule Localization MicroscopyData Using Cubic Splines

This paper introduces cubic splines as an alternative to analytical functions for PSF fitting in 3D single molecule localization microscopy, showing high accuracy with minimal increased computation time.