J. A. McKeating

CTCF regulates hepatitis B virus cccDNA chromatin topology

This study shows that CTCF regulates HBV cccDNA chromatin topology and nucleosomal positioning, affecting viral transcription.

Circadian regulation of human immunodeficiency virus type 1 replication

This study shows HIV-1 replication is regulated by circadian rhythms through interactions between transcription factors BMAL1, REV-ERB, and ROR, with implications for HIV therapy.

An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity

This paper shows that ACAT inhibitors like Avasimibe reduce SARS-CoV-2 replication and enhance antiviral T cell activity in patients.

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.

This study shows that activating HIF signaling reduces SARS-CoV-2 infection and respiratory symptoms in hamsters by decreasing viral RNA and epithelial damage.

Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences

The paper quantifies SARS-CoV-2 RNA molecules using smFISH, revealing genomic RNA stability, cell-to-cell replication variability, and slower replication kinetics for the B.1.1.7 variant compared to the Victoria strain.

Supramolecular cylinders target bulge structures in the 5-prime UTR of the RNA genome of SARS-CoV-2 and inhibit viral replication

The paper models the 5' UTR structure of SARS-CoV-2 and shows supramolecular cylinders bind to a bulge and junction, inhibiting viral replication.

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

This study shows BMAL1 regulates ACE2 expression and SARS-CoV-2 entry in lung epithelial cells, with SR9009 reducing viral replication through circadian mechanisms.

The CCCTC-binding factor CTCF represses hepatitis B virus Enhancer I and regulates viral transcription

This study identifies CTCF as a repressor of HBV transcription by binding to Enhancer I and reducing pre-genomic RNA levels.

Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

This study shows that REV-ERB agonists inhibit HIV-1 replication by suppressing its promoter activity in multiple cell types.

Synchronized infection identifies early rate-limiting steps in the hepatitis B virus life cycle.

This study uses synchronized infection to analyze HBV entry and cccDNA formation, finding that most viral particles enter cells but only a small fraction becomes cccDNA, highlighting a rate-limiting step in infection.

Hypoxic gene expression in chronic hepatitis B infected patients is not observed in state-of-art in vitro and mouse infection models

The paper shows hypoxia gene upregulation in chronic hepatitis B patients is not observed in in vitro or mouse models, suggesting inflammatory factors may drive this effect.