Author

C. L. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. B. Coley· 2 shared B. C. Watters· 2 shared C. H. McInnis· 2 shared D. Houserova· 2 shared G. M. Borchert· 2 shared J. D. DeMeis· 2 shared J. Huang· 2 shared J. T. Roberts· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. B. Coley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification of Natural Antiviral Drug Candidates Against Tilapia Lake Virus: Computational Drug Design Approaches

C. L. Brown, M. A. A. Sumon, A. H. Asseri, M. H. R. Molla, M. O. Aljahdali, M. R. Hasan, M. A. Rahman, M. T. Hasan, T. A. Sumon, M. H. Gabr, M. S. Islam, B. Fakhurji, M. Moulay, E. Larson

This study identifies potential antiviral compounds from two mangrove plants targeting CRM1 protein to inhibit Tilapia Lake Virus using computational methods.

bioRxiv · Jun 19, 2023Pharmacology & Toxicology

MicroRNA-like snoRNA-derived RNAs (sdRNAs) promote castration resistant prostate cancer

A. B. Coley, A. N. Stahly, M. V. Kasukurthi, A. A. Barchie, S. B. Hutcheson, D. Houserova, Y. Huang, B. C. Watters, V. M. King, M. A. Dean, J. T. Roberts, J. D. DeMeis, C. H. McInnis, N. L. Godang, R. M. Wright, , G. M. Borchert

This study identifies two snoRNA-derived fragments, sdRNA-D19b and sdRNA-A24, that promote castration-resistant prostate cancer by downregulating tumor suppressors and conferring drug resistance.

bioRxiv · Dec 17, 2021Cancer Biology

Salmonella Outer Membrane Vesicles contain tRNA Fragments (tRFs) that Inhibit Bacteriophage P22 infection

D. Houserova, Y. Huang, M. V. Kasukurthi, B. C. Watters, F. F. Khan, R. V. Mehta, N. Y. Chaudhary, J. T. Roberts, J. D. DeMeis, T. K. Hobbs, K. R. Ghee, C. H. McInnis, N. P. Johns, A. J. Kegler, A. B. Coley, , G. M. Borchert

This study identifies tRNA fragments (tRFs) in Salmonella OMVs that inhibit bacteriophage P22 infection, showing their role in antiviral defense.

bioRxiv · Nov 9, 2021 · PreprintMicrobiology

A derivative of the D5 monoclonal antibody that targets the gp41 N-heptad repeat of HIV-1 with broad tier-2 neutralizing activity

A. A. Rubio, M. V. Filsinger Interrante, B. N. Bell, C. L. Brown, C. C. LaBranche, D. C. Montefiori, P. S. Kim

This paper describes the engineering of a D5 monoclonal antibody variant, D5_AR, which shows enhanced neutralizing activity against tier-2 HIV-1 strains and improved potency in cells expressing FcγRI.

bioRxiv · Oct 23, 2020Immunology

Whole genome sequence analysis reveals broad distribution of the RtxA type 1 secretion system and four novel type 1 secretion systems throughout the Legionella genus

C. L. Brown, E. Garner, G. Jospin, D. A. Coil, D. O. Schwake, J. A. Eisen, B. Mukhopadhyay, A. Pruden

The paper analyzes whole genome sequences of Legionella species to reveal the broad distribution of the RtxA type 1 secretion system and four novel T1SSs, challenging the view of RtxA as a conserved virulence factor.

bioRxiv · Sep 13, 2019Microbiology