P. S. Kim

Evolution of human pair bonds as a consequence of male-biased mating sex ratios?

The paper models the evolution of human pair bonds by simulating male mating strategies under different sex ratio conditions and finds that higher sex ratios favor mate-guarding over multiple mating.

Design of universal Ebola virus vaccine candidates via immunofocusing

This paper designs universal Ebola virus vaccine candidates using hyperglycosylation to focus antibody responses on conserved epitopes, showing cross-neutralizing activity against multiple orthoebolavirus species.

Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced from two different cell lines

This study develops and compares an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced in two cell lines, showing similar immunogenicity despite differences in glycoforms.

Decreased efficacy of a COVID-19 vaccine due to mutations present in early SARS-CoV-2 variants of concern

This study evaluates the efficacy of a pan-sarbecovirus vaccine candidate against SARS-CoV-2 variants, finding that omitting strain-specific mutations improves cross-reactive neutralizing antibody responses.

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

This paper describes a ferritin-based nanoparticle vaccine, DCFHP-alum, that induces strong, long-lasting neutralizing antibodies against SARS-CoV-2 variants in non-human primates.

Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies

This study shows that stabilizing the HIV-1 gp41 hydrophobic pocket with a modified peptide improves antibody response and neutralizing activity against HIV-1.

Designing epitope-focused vaccines via antigen reorientation

This paper introduces an antigen reorientation strategy using oligoD insertion to shift immune responses toward conserved epitopes, demonstrating improved cross-reactivity in influenza vaccines.

Enhancing HIV-1 neutralization by increasing the local concentration of MPER directed bnAbs

This paper shows that increasing local concentration of MPER-directed bnAbs via Fc{gamma}RI binding enhances HIV-1 neutralization, suggesting lipid-binding is not strictly required for potency.

HIV-1 neutralization tiers are not relevant for inhibitors targeting the pre-hairpin intermediate

The paper shows that HIV-1 neutralization tiers do not predict the potency of inhibitors targeting the pre-hairpin intermediate, unlike broadly neutralizing antibodies.

Examining the efficacy of localised gemcitabine therapy for the treatment of pancreatic cancer using a hybrid agent-based model

This paper develops a hybrid computational model to evaluate the efficacy of gemcitabine-loaded alginate fibres for treating pancreatic cancer, finding that intratumoural placement is more effective than peritumoural placement.

Converting non-neutralizing SARS-CoV-2 antibodies targeting conserved epitopes into broad-spectrum inhibitors through receptor blockade

This paper converts non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitors by tethering ACE2 to conserved epitope-targeting antibodies, showing potent neutralization against all variants including Omicron.

Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2

This study shows that slow release of an RBD subunit vaccine via hydrogel enhances neutralizing antibody responses against SARS-CoV-2 compared to bolus administration.

Neutralizing antibodies targeting the SARS-CoV-2 receptor binding domain isolated from a naïve human antibody library

The paper isolates and characterizes three novel neutralizing antibodies against SARS-CoV-2 RBD from a naive human antibody library, showing they neutralize the virus in vitro.

A minimal model of T cell avidity may identify subtherapeutic vaccine schedules

This paper develops a minimal mathematical model of T cell avidity to identify vaccine schedules that favor low-avidity T cells by analyzing parameter sensitivity and clinical data.

A derivative of the D5 monoclonal antibody that targets the gp41 N-heptad repeat of HIV-1 with broad tier-2 neutralizing activity

This paper describes the engineering of a D5 monoclonal antibody variant, D5_AR, which shows enhanced neutralizing activity against tier-2 HIV-1 strains and improved potency in cells expressing FcγRI.

A single immunization with spike-functionalized ferritin vaccines elicits neutralizing antibody responses against SARS-CoV-2 in mice

This study shows that a single dose of spike-functionalized ferritin vaccines in mice generates neutralizing antibodies against SARS-CoV-2, with S{Delta}C-Fer showing higher efficacy than other spike formats.

The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat

This paper shows that the FcγRI receptor enhances HIV-1 neutralization by NHR-targeting antibodies, enabling neutralization of tier-2 viruses.

Immature dendritic cells promote high avidity tuning of vaccine T cell response

This study shows that immature dendritic cells can enhance high-avidity T cell responses to vaccines by reducing peptide:MHC complex load.

A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery

The paper identifies a high-affinity human PD-1/PD-L2 complex structure and demonstrates a small-molecule drug target through mutagenesis and crystallography.

Enhancing natural killer cell function with gp41-targeting bispecific antibodies to combat HIV infection

This study develops bispecific antibodies targeting HIV gp41 and NK cell CD16 to enhance ADCC against HIV-infected cells, showing improved degranulation and killing of infected targets.

FLASH: A next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

FLASH is a CRISPR-based diagnostic method that enhances detection of low-abundance antimicrobial resistance sequences in metagenomic data.

Functional Enrichment and Analysis of Antigen-Specific Memory B Cell Antibody Repertoires in PBMCs

The paper functionally expands and maps monoclonal antibodies from memory B cells in PBMCs to assess immune protection.

Protect, Modify, Deprotect (PMD): A strategy for creating vaccines to elicit antibodies targeting a specific epitope

This paper introduces PMD, a method to create vaccines that direct antibody responses toward specific epitopes by protecting, modifying, and deprotecting antigens.

PfClpC Is An Essential Clp Chaperone Required For Plastid Integrity And Clp Protease Stability In Plasmodium falciparum

This paper identifies PfClpC as an essential apicoplast-targeted chaperone in Plasmodium falciparum, showing its role in maintaining apicoplast integrity and parasite viability.