Author

C. C. LaBranche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:variant calling· 3 Research Focus:drug response / drug discovery· 2 Organism:rat· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. C. Montefiori· 4 shared A. A. Rubio· 2 shared B. N. Bell· 2 shared M. V. Filsinger Interrante· 2 shared P. S. Kim· 2 shared A. A. Lackner· 1 shared A. Bartesaghi· 1 shared A. Foulger· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersImmunology

D. C. Montefiori

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A tyrosine-based trafficking signal in the simian immunodeficiency virus envelope cytoplasmic domain is strongly selected for in pathogenic SIV infection

S. Lawrence, S. E. Elser, W. Torben, R. V. Blair, B. Pahar, P. P. Aye, F. Schiro, D. Szeltner, L. A. Doyle-Meyers, B. Haggarty, A. O. Jordan, J. Romano, X. Alvarez, D. H. O'Connor, R. W. Wiseman, , J. A. Hoxie

This study shows that a tyrosine-based trafficking signal in SIV Env is strongly selected for during pathogenic infection, as mutations reconstitute endocytosis and polarized sorting signals.

bioRxiv · Mar 31, 2021 · PreprintCell Biology

A derivative of the D5 monoclonal antibody that targets the gp41 N-heptad repeat of HIV-1 with broad tier-2 neutralizing activity

A. A. Rubio, M. V. Filsinger Interrante, B. N. Bell, C. L. Brown, C. C. LaBranche, D. C. Montefiori, P. S. Kim

This paper describes the engineering of a D5 monoclonal antibody variant, D5_AR, which shows enhanced neutralizing activity against tier-2 HIV-1 strains and improved potency in cells expressing FcγRI.

bioRxiv · Oct 23, 2020Immunology

The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat

D. C. Montefiori, M. V. Filsinger Interrante, B. N. Bell, A. A. Rubio, J. G. Joyce, J. W. Shiver, C. C. LaBranche, P. S. Kim

This paper shows that the FcγRI receptor enhances HIV-1 neutralization by NHR-targeting antibodies, enabling neutralization of tier-2 viruses.

bioRxiv · Aug 27, 2020Immunology

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

W. B. Williams, R. Meyerhoff, R. J. Edwards, H. Li, N. Nicely, R. Henderson, Y. Zhou, K. Janowska, K. Mansouri, K. Manne, V. Stalls, A. L. Hsu, M. J. Borgnia, G. Stewart-Jones, M. S. Lee, , B. F. Haynes

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

bioRxiv · Jun 30, 2020 · PreprintImmunology

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

B. Korber, W. Fischer, S. G. Gnanakaran, H. Yoon, J. Theiler, W. Abfalterer, B. Foley, E. E. Giorgi, T. Bhattacharya, M. D. Parker, D. G. Partridge, C. M. Evans, T. de Silva, C. C. LaBranche, D. C. Montefiori, Sheffield COVID-19 Genomics Group

The paper develops a pipeline to track SARS-CoV-2 mutations in the Spike protein, identifying D614G as a rapidly spreading mutation with potential implications for transmission and immune evasion.

bioRxiv · Apr 29, 2020Evolutionary Biology