Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen
B. Alarcon, A. Martinez-Riano, P. Delgado, P. Mendoza, C. L. Oeste, D. Abia, E. R. Bovolenta, M. Turner
This study recreates an antigen-driven germinal center in vitro using B and T cells, demonstrating the generation of high-affinity immunoglobulins through phagocytic antigen uptake.
bioRxiv · Feb 26, 2020 · PreprintImmunology