Author

P. Mendoza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:human· 7 Assay:proteomics· 5 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. Caskey· 7 shared C. Gaebler· 6 shared M. C. Nussenzweig· 6 shared A. Cho· 4 shared A. Gazumyan· 4 shared F. Muecksch· 4 shared F. Schmidt· 4 shared M. Cipolla· 4 shared

Activity by Year

2020-2021 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersImmunology

M. Caskey

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Anti- SARS-CoV-2 Receptor Binding Domain Antibody Evolution after mRNA Vaccination

A. Cho, F. Muecksch, D. Schaefer-Babajew, Z. Wang, S. Finkin, C. Gaebler, V. Ramos, M. Cipolla, P. Mendoza, M. Agudelo, E. Bednarski, J. DaSilva, I. Shimeliovich, J. Dizon, M. Daga, , M. C. Nussenzweig

This study examines memory B cell evolution 5 months after mRNA vaccination in naive individuals, finding increased neutralizing activity but no further breadth or potency, and higher overall plasma neutralizing potency compared to natural infection.

bioRxiv · Jul 29, 2021Immunology

Persistent Cellular Immunity to SARS-CoV-2 Infection

G. Breton, P. Mendoza, T. Hagglof, T. Y. Oliveira, D. Schaefer-Babajew, C. Gaebler, M. Turroja, A. Hurley, M. Caskey, M. C. Nussenzweig

The paper shows that SARS-CoV-2 infection leads to persistent, functional memory T cell responses and enduring immune alterations in CD4+ and CD8+ T cells six months post-infection.

bioRxiv · Dec 8, 2020Immunology

Evolution of Antibody Immunity to SARS-CoV-2

C. Gaebler, Z. Wang, J. C. C. Lorenzi, F. Muecksch, S. Finkin, M. Tokuyama, A. Cho, M. Jankovic, D. Schaefer-Babajew, T. Y. Oliveira, M. Cipolla, C. Viant, C. O. Barnes, A. Hurley, M. Turroja, , R. Patel

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

bioRxiv · Nov 3, 2020Immunology

Neutralizing activity of broadly neutralizing anti-HIV-1 antibodies against primary African isolates

J. C. C. Lorenzi, P. Mendoza, Y. Z. Cohen, L. Nogueira, C. Lavine, J. Sapiente, M. Seaman, M. Wiatr, N. R. Mugo, A. Mujugira, S. Delany, J. R. Lingappa, C. Celum, M. Caskey, M. C. Nussenzweig

This study evaluates the neutralizing activity of 9 anti-HIV-1 bNAbs against primary African isolates, finding reduced potency and breadth compared to pseudotyped viruses.

bioRxiv · Sep 24, 2020Immunology

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

F. Schmidt, Y. Weisblum, F. Muecksch, H.-H. Hoffmann, E. Michailidis, J. C. C. Lorenzi, P. Mendoza, M. Rutkowska, E. Bednarski, C. Gaebler, M. Agudelo, A. Cho, Z. Wang, A. Gazumyan, M. Cipolla, , P. D. Bieniasz

The paper describes assays using pseudotyped and chimeric viruses to measure SARS-CoV-2 neutralizing antibody activity, showing correlation with authentic assays.

bioRxiv · Jun 8, 2020Microbiology

Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals

D. F. Robbiani, C. Gaebler, F. Muecksch, J. Cetrulo Lorenzi, Z. Wang, A. Cho, M. Agudelo, C. Barnes, S. Finkin, T. Hagglof, T. Oliveira, C. Viant, A. Hurley, K. Millard, R. Kost, , Nuss

The paper analyzes antibody responses in convalescent individuals, finding low neutralizing titers but rare potent RBD-specific antibodies with broad antiviral potential.

bioRxiv · May 13, 2020Immunology

Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen

B. Alarcon, A. Martinez-Riano, P. Delgado, P. Mendoza, C. L. Oeste, D. Abia, E. R. Bovolenta, M. Turner

This study recreates an antigen-driven germinal center in vitro using B and T cells, demonstrating the generation of high-affinity immunoglobulins through phagocytic antigen uptake.

bioRxiv · Feb 26, 2020 · PreprintImmunology

Antigen responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir

P. Mendoza, J. R. Jackson, T. Oliveira, C. Gaebler, V. Ramos, M. Caskey, M. Jankovic, M. C. Nussenzweig, L. B. Cohn

The paper shows that antigen-responsive CD4+ T cell clones with latent HIV-1 proviruses persist in individuals, suggesting antigen exposure contributes to reservoir longevity.

bioRxiv · Jan 10, 2020Immunology