Author

C. L. White

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 3 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Assay:imaging· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. I. Diamond· 3 shared A. C. McKee· 2 shared A. R. Vega· 2 shared D. A. Dodd· 2 shared G. Marx· 2 shared J. F. Crary· 2 shared J. K. Kofler· 2 shared J. M. Walker· 2 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

M. I. Diamond

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Interpretable deep learning of myelin histopathology in age-related cognitive impairment

A. T. McKenzie, G. Marx, D. Koenigsberg, M. Sawyer, M. A. Iida, J. M. Walker, T. E. Richardson, G. Campanella, J. Attems, A. C. McKee, T. D. Stein, T. J. Fuchs, C. L. White, The PART Working Group, K. Farrell, J. F. Crary

This study uses interpretable deep learning to identify myelin pallor in brain tissue associated with cognitive impairment from postmortem human samples.

bioRxiv · Jun 6, 2022Pathology

Tau seeds translocate across the cell membrane to initiate aggregation

D. A. Dodd, M. S. LaCroix, C. Valdez, G. M. Knox, A. R. Vega, A. Kumar, C. Xing, C. L. White, M. I. Diamond

This study identifies a novel mechanism by which tau seeds enter cells and initiate aggregation through direct translocation across the plasma membrane, independent of endocytosis.

bioRxiv · May 10, 2022 · PreprintCell Biology

RNA induces unique tau strains and stabilizes Alzheimer disease seeds

A. Zwierzchowski-Zarate, O. M. Kashmer, J. E. Collazo-Lopez, C. L. White, M. I. Diamond

The paper shows RNA, specifically polyA, induces stable tau strains and may contribute to Alzheimer's disease pathology by promoting seed formation.

bioRxiv · Jan 29, 2022Biochemistry

Dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification

S. Kolay, A. R. Vega, D. A. Dodd, V. A. Perez, O. M. Kashmer, C. L. White, M. I. Diamond

This study investigates how exogenous tau seeds are cleared or amplified within cells, finding they are mostly lysosomally degraded but a small fraction enters the cytosol to replicate and is cleared by the proteasome.

bioRxiv · Jan 3, 2022Cell Biology

Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study

M. A. Iida, K. Farrell, J. M. Walker, T. E. Richardson, G. Marx, C. H. Bryce, D. Purohit, G. Ayalon, T. G. Beach, E. H. Bigio, E. Cortes, M. Gearing, V. Haroutunian, C. T. McMillan, E. B. Lee, , J. F. Crary

This study identifies predictors of cognitive impairment in primary age-related tauopathy (PART) using autopsy data, finding that p-tau burden and cerebrovascular disease are significant predictors.

bioRxiv · Jun 8, 2021 · PreprintPathology

Deep learning from multiple experts improves identification of amyloid neuropathologies

D. R. Wong, Z. Tang, N. C. Mew, S. Das, J. Athey, K. E. McAleese, J. K. Kofler, M. E. Flanagan, E. Borys, C. L. White, A. J. Butte, B. N. Dugger, M. J. Keiser

The paper develops a deep learning model that combines multiple expert annotations to improve the identification of amyloid neuropathologies, achieving consistent diagnoses across varying expert opinions.

bioRxiv · Mar 12, 2021Pathology