Author

O. M. Kashmer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 1

Frequent Co-Authors

M. I. Diamond· 5 shared C. L. White· 2 shared D. R. Woodard· 2 shared V. A. Perez· 2 shared A. Lemoff· 1 shared A. M. Sharma· 1 shared A. R. Vega· 1 shared A. Zwierzchowski-Zarate· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersCell Biology

M. I. Diamond

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Author profile →

5 papers

Recent·Most cited

VCP increases or decreases tau seeding using specific cofactors

S. Batra, J. I. Vaquer-Alicea, V. A. Manon, O. M. Kashmer, A. Lemoff, N. J. Cairns, C. L. I. White, M. I. Diamond

This study investigates how VCP and its cofactors influence tau seeding efficiency in cellular models, finding that VCP modulates this process through distinct cofactors.

bioRxiv · Aug 30, 2023Cell Biology

RNA induces unique tau strains and stabilizes Alzheimer disease seeds

A. Zwierzchowski-Zarate, O. M. Kashmer, J. E. Collazo-Lopez, C. L. White, M. I. Diamond

The paper shows RNA, specifically polyA, induces stable tau strains and may contribute to Alzheimer's disease pathology by promoting seed formation.

bioRxiv · Jan 29, 2022Biochemistry

Dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification

S. Kolay, A. R. Vega, D. A. Dodd, V. A. Perez, O. M. Kashmer, C. L. White, M. I. Diamond

This study investigates how exogenous tau seeds are cleared or amplified within cells, finding they are mostly lysosomally degraded but a small fraction enters the cytosol to replicate and is cleared by the proteasome.

bioRxiv · Jan 3, 2022Cell Biology

Tau local structure shields amyloid motif and controls aggregation propensity

D. Chen, K. W. Drombosky, Z. Hou, L. Sari, O. M. Kashmer, B. D. Ryder, V. A. Perez, D. R. Woodard, M. Lin, M. I. Diamond, L. A. Joachimiak

The paper investigates how local structure in tau protein modulates aggregation propensity and how mutations disrupt this structure to trigger amyloid formation.

bioRxiv · Jan 2, 2019 · PreprintBiophysics

Tau monomer encodes strains

A. M. Sharma, T. L. Thomas, D. R. Woodard, O. M. Kashmer, M. I. Diamond

The paper shows that tau monomer can encode multiple stable strains, leading to distinct neuropathologies in mice.

bioRxiv · May 17, 2018Biochemistry