Author

A. R. Vega

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. L. White· 2 shared D. A. Dodd· 2 shared K. Jaqaman· 2 shared M. I. Diamond· 2 shared A. Dasgupta· 1 shared A. Kumar· 1 shared A. Lakoduk· 1 shared B. da Rocha-Azevedo· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

C. L. White

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Author profile →

4 papers

Recent·Most cited

Tau seeds translocate across the cell membrane to initiate aggregation

D. A. Dodd, M. S. LaCroix, C. Valdez, G. M. Knox, A. R. Vega, A. Kumar, C. Xing, C. L. White, M. I. Diamond

This study identifies a novel mechanism by which tau seeds enter cells and initiate aggregation through direct translocation across the plasma membrane, independent of endocytosis.

bioRxiv · May 10, 2022 · PreprintCell Biology

Dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification

S. Kolay, A. R. Vega, D. A. Dodd, V. A. Perez, O. M. Kashmer, C. L. White, M. I. Diamond

This study investigates how exogenous tau seeds are cleared or amplified within cells, finding they are mostly lysosomally degraded but a small fraction enters the cytosol to replicate and is cleared by the proteasome.

bioRxiv · Jan 3, 2022Cell Biology

Heterogeneity in VEGF Receptor-2 mobility and organization on the endothelial cell surface leads to diverse activation models by VEGF

B. da Rocha-Azevedo, S. Lee, A. Dasgupta, A. R. Vega, L. R. de Oliveira, T. Kim, M. Kittisopikul, K. Jaqaman

This study examines VEGFR-2 mobility and organization on endothelial cells, revealing how receptor heterogeneity influences VEGF activation mechanisms.

bioRxiv · Jan 21, 2020Biophysics

A Composition-Dependent Molecular Clutch Between T Cell Signaling Clusters and Actin

J. A. Ditlev, A. R. Vega, D. V. Köster, X. Su, A. Lakoduk, R. D. Vale, S. Mayor, K. Jaqaman, M. K. Rosen

The paper investigates how Nck and WASP mediate the movement of LAT condensates across actin networks during T cell activation.

bioRxiv · Oct 15, 2018Cell Biology