Author

C. L. Wiser

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Immunology· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

B. Kim· 1 shared J. N. Vincent· 1 shared M. Ascano· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperImmunology

B. Kim

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1 paper

Recent·Most cited

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells

C. L. Wiser, B. Kim, J. N. Vincent, M. Ascano

This study shows that RU.521 inhibits human and mouse cGAS, reducing cGAMP production and cytokine expression in response to dsDNA, without affecting RNA or interferon-induced responses.

bioRxiv · Mar 30, 2020Immunology