C. M. Furman

Formation of the active Hermes transpososome is driven by asymmetric DNA binding of BED domains

The paper investigates how the Hermes transposase forms an active tetramer and shows that it binds asymmetrically to the transposon ends, with stronger interaction at the left-end through BED domains.

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex.

The paper shows that intrinsically disordered regions in the yeast MutL complex regulate both DNA binding and enzymatic activities essential for mismatch repair.