Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation
J. S. Duke-Cohan, A. Akitsu, R. J. Mallis, C. M. Messier, P. H. Lizotte, W. Hwang, M. J. Lang, E. L. Reinherz
The paper shows that preTCR-pMHC interactions prevent thymocyte dedifferentiation by analyzing single-cell transcriptomes in fetal thymic cultures with and without pMHC.
bioRxiv · Apr 28, 2022Immunology