Author

R. J. Mallis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

M. J. Lang· 3 shared A. Akitsu· 2 shared E. Reinherz· 2 shared J. S. Duke-Cohan· 2 shared W. Hwang· 2 shared A. C. Chang-Gonzalez· 1 shared C. M. Messier· 1 shared D. J. Masi· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

M. J. Lang

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3 papers

Recent·Most cited

Parsing digital or analogue TCR performance through piconewton forces

A. Akitsu, E. Kobayashi, Y. Feng, H. M. Stephens, K. N. Brazin, D. J. Masi, E. H. Kirpatrick, R. J. Mallis, J. S. Duke-Cohan, M. A. Booker, V. Cinella, W. W. Feng, E. L. Holliday, J. J. Lee, K. J. Zienkiewicz, , E. Reinherz

The paper examines how TCR performance differs under physical force, finding digital TCRs are more effective in vivo.

bioRxiv · Nov 29, 2023 · PreprintImmunology

Asymmetric framework motion of TCR alpha beta controls load-dependent peptide discrimination

A. C. Chang-Gonzalez, R. J. Mallis, M. J. Lang, E. Reinherz, W. Hwang

The paper uses molecular dynamics simulations to show how asymmetric motion of TCR alpha beta chains affects peptide discrimination under mechanical force.

bioRxiv · Sep 10, 2023Biophysics

Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation

J. S. Duke-Cohan, A. Akitsu, R. J. Mallis, C. M. Messier, P. H. Lizotte, W. Hwang, M. J. Lang, E. L. Reinherz

The paper shows that preTCR-pMHC interactions prevent thymocyte dedifferentiation by analyzing single-cell transcriptomes in fetal thymic cultures with and without pMHC.

bioRxiv · Apr 28, 2022Immunology