Nutrient copper signaling promotes protein turnover by allosteric activation of ubiquitin E2D conjugases
C. M. Opazo, A. Lotan, Z. Xiao, B. Zhang, M. A. Greenough, C. M. Lim, H. Trytell, A. Ramirez, A. A. Ukuwela, C. H. Mawal, J. McKenna, D. N. Saunders, R. Burke, P. R. Gooley, A. I. Bush
This paper shows that copper signaling modulates protein turnover by allosterically activating ubiquitin E2D conjugases, linking copper levels to protein degradation and morphogenesis.
bioRxiv · Feb 15, 2021 · PreprintCell Biology