Author

A. I. Bush

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. A. Ukuwela· 1 shared A. Lotan· 1 shared A. Ramirez· 1 shared B. Zhang· 1 shared C. Cortez-Jugo· 1 shared C. H. Mawal· 1 shared C. M. Lim· 1 shared C. M. Opazo· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCell Biology

A. A. Ukuwela

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Author profile →

2 papers

Recent·Most cited

mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

D. Furtado, C. Cortez-Jugo, Y. H. Hung, A. I. Bush, F. Caruso

This paper demonstrates that engineered mRNA can restore NPC1 protein function and correct the pathogenic phenotype in NP-C1 patient fibroblasts.

bioRxiv · Feb 21, 2022Bioengineering

Nutrient copper signaling promotes protein turnover by allosteric activation of ubiquitin E2D conjugases

C. M. Opazo, A. Lotan, Z. Xiao, B. Zhang, M. A. Greenough, C. M. Lim, H. Trytell, A. Ramirez, A. A. Ukuwela, C. H. Mawal, J. McKenna, D. N. Saunders, R. Burke, P. R. Gooley, A. I. Bush

This paper shows that copper signaling modulates protein turnover by allosterically activating ubiquitin E2D conjugases, linking copper levels to protein degradation and morphogenesis.

bioRxiv · Feb 15, 2021 · PreprintCell Biology