C. M. Ruiz

Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats

This study examines how adolescent THC exposure affects dopamine-dependent cognitive processes in adult rats, finding sex-dependent impacts on reward seeking and altered sensitivity to amphetamine effects.

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.

Stabilization of cultural innovations depends on population density: testing an epidemiological model of cultural evolution against a global dataset of rock art sites and climate-based estimates of ancient population densities.Short title: Cultural epidemiology: the case of rock art

The paper tests an epidemiological model of cultural evolution using rock art data and population density estimates, finding that population density above a critical threshold is necessary for cultural innovation stability.