Cachexia and fibrosis are costs of chronic IL-1R-mediated disease tolerance in T. gondii infection
S. E. Ewald, S. J. Melchor, J. A. Hatter, E. A. LaTorre Castillo, C. M. Saunders, K. A. Byrnes, I. Sanders, D. Abebayehu, T. Barker, S. Countermarsh-Ott
This study shows that IL-1R signaling protects mice from acute T. gondii infection but leads to chronic cachexia and fibrosis when sustained.
bioRxiv · Sep 26, 2019 · PreprintImmunology