Author
S. E. Ewald
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2018-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 12 mutual co-author links9 papers
Recent·Most cited
Tricarboxylic acid (TCA) cycle, sphingolipid, and phosphatidylcholine metabolism are dysregulated in T. gondii infection-induced cachexia
T.-Y. Feng, S. J. Melchor, H. Ghumman, M. Kester, T. E. Fox, S. E. Ewald
The paper identifies metabolic dysregulation in T. gondii infection-induced cachexia, showing increased sphingolipids and phosphatidylcholines and decreased TCA cycle intermediates in mouse sera.
bioRxiv · Dec 20, 2022 · PreprintImmunology
Myeloid-mediated IL-1R signaling in immuno-responsive Thy-1 negative fibroblasts is critical for pulmonary fibrosis
D. Abebayehu, C.-R. Yeh, G. C. Bingham, S. E. Ewald, T. H. Barker
This study identifies Thy-1 negative fibroblasts as immuno-responsive cells that link inflammation and mechanotransduction in pulmonary fibrosis through IL-1R signaling.
bioRxiv · May 11, 2021 · PreprintCell Biology
Automated Spatially Targeted Optical Micro Proteomics (AutoSTOMP) 2.0 identifies proteins enriched within inflammatory lesions in tissue sections and human clinical biopsies.
B. YIN, L. R. Caggiano, R.-C. Li, E. McGowan, J. W. Holmes, S. E. Ewald
AutoSTOMP 2.0 identifies proteins in specific regions of tissue sections and biopsies, revealing inflammatory proteins in cardiac infarcts and IgG4+ lesions.
bioRxiv · Mar 19, 2021 · PreprintImmunology
Cellular barcoding of protozoan pathogens reveals the within-host population dynamics of Toxoplasma gondii host colonization
C. J. Wincott, G. Sritharan, H. J. Benns, F. B. Liakath, C. Gilabert-Carbajo, M. Bunyan, A. Fairweather, E. Alves, I. Andrews, L. Game, E. M. Frickel, C. Tiengwe, S. E. Ewald, M. A. Child
The paper develops a CRISPR-based barcoding method for protozoa and applies it to Toxoplasma gondii, showing the blood-brain barrier is not a major bottleneck for colonization.
bioRxiv · Aug 6, 2020Microbiology
Differential protein phosphorylation affects the localisation of two secreted Toxoplasma proteins and is widespread during stage conversion
J. Young, M. Broncel, H. Teague, M. R. Russell, O. McGovern, M. Renshaw, D. Frith, A. P. Snijders, L. M. Collinson, V. B. Carruthers, S. E. Ewald, M. Treeck
This paper investigates the role of phosphorylation in regulating the localization of two secreted Toxoplasma proteins during stage conversion and identifies widespread differential phosphorylation of secreted proteins.
bioRxiv · Apr 9, 2020 · PreprintMicrobiology
Cachexia and fibrosis are costs of chronic IL-1R-mediated disease tolerance in T. gondii infection
S. E. Ewald, S. J. Melchor, J. A. Hatter, E. A. LaTorre Castillo, C. M. Saunders, K. A. Byrnes, I. Sanders, D. Abebayehu, T. Barker, S. Countermarsh-Ott
This study shows that IL-1R signaling protects mice from acute T. gondii infection but leads to chronic cachexia and fibrosis when sustained.
bioRxiv · Sep 26, 2019 · PreprintImmunology
Automated Spatially Targeted Optical Micro Proteomics (autoSTOMP) to determine protein complexity of subcellular structures
B. Yin, R. C. Mendez, X. Zhao, R. Rahkit, K.-L. Hsu, S. E. Ewald
The paper introduces autoSTOMP, an automated protocol for spatially targeted optical micro proteomics, enabling efficient protein analysis of subcellular structures in human and mouse cells.
bioRxiv · Sep 26, 2019Biochemistry
Toxoplasma gondii infection triggers chronic cachexia and sustained commensal dysbiosis in mice
J. A. Hatter, S. J. Melchore, M. Kouch, K. Ng, D. W. Bouley, J. C. Boothroyd, S. E. Ewald
This study shows that Toxoplasma gondii infection in mice causes chronic cachexia and sustained gut microbiota changes, but not all microbiota alterations are sufficient to cause cachexia.
bioRxiv · Jan 25, 2018Microbiology