Author

S. J. Melchor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

S. E. Ewald· 2 shared A. E. Ross· 1 shared A. G. Ball· 1 shared A. W. L. Kinman· 1 shared B. D. Groff· 1 shared C. M. Saunders· 1 shared D. Abebayehu· 1 shared E. A. LaTorre Castillo· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

S. E. Ewald

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Author profile →

3 papers

Recent·Most cited

Tricarboxylic acid (TCA) cycle, sphingolipid, and phosphatidylcholine metabolism are dysregulated in T. gondii infection-induced cachexia

T.-Y. Feng, S. J. Melchor, H. Ghumman, M. Kester, T. E. Fox, S. E. Ewald

The paper identifies metabolic dysregulation in T. gondii infection-induced cachexia, showing increased sphingolipids and phosphatidylcholines and decreased TCA cycle intermediates in mouse sera.

bioRxiv · Dec 20, 2022 · PreprintImmunology

Acute lymph node slices are a functional model system to study immunity ex vivo

M. C. Belanger, A. G. Ball, M. A. Catterton, A. W. L. Kinman, P. Anbaei, B. D. Groff, S. J. Melchor, J. R. Lukens, A. E. Ross, R. R. Pompano

This study validates live murine lymph node slices as a functional ex vivo model to study immune responses while preserving spatial organization and dynamic accessibility.

bioRxiv · Dec 28, 2020Immunology

Cachexia and fibrosis are costs of chronic IL-1R-mediated disease tolerance in T. gondii infection

S. E. Ewald, S. J. Melchor, J. A. Hatter, E. A. LaTorre Castillo, C. M. Saunders, K. A. Byrnes, I. Sanders, D. Abebayehu, T. Barker, S. Countermarsh-Ott

This study shows that IL-1R signaling protects mice from acute T. gondii infection but leads to chronic cachexia and fibrosis when sustained.

bioRxiv · Sep 26, 2019 · PreprintImmunology