A Liquid Chromatography-Mass Spectrometry Method For Screening Disulfide Tethering Fragments
K. K. Hallenbeck, J. Davies, C. Merron, P. Ogden, E. Sijbesma, C. Ottmann, A. R. Renslo, C. Wilson, M. R. Arkin
The paper refines an LC/MS-based method for screening covalent small-molecule binders to proteins, achieving fast and reliable screening over multiple projects.
bioRxiv · Aug 4, 2017Biophysics