J. Davies

Community phylogenetic structure shapes pathogen outbreak potential in an epidemiological multi-host model

The paper models how community phylogenetic structure influences disease outbreak potential in a multi-host system, showing that phylogenetic relatedness can shift communities from diluting to amplifying disease.

Neutron capture enhances dose and reduces cancer cell viability in and out of beam during helium and carbon ion therapy.

This paper demonstrates that neutron capture agents enhance radiation dose and reduce cancer cell viability during carbon and helium ion therapy, both within and adjacent to the treatment volume.

Leveraging machine learning and citizen science data to describe flowering phenology across South Africa

The paper uses machine learning to classify flowering phenology from citizen science images, revealing peak flower production and flowering season length for many South African plant species.

Cryptococcus displays spore-specific invasion of alveolar epithelial cells

This study shows Cryptococcus spores invade alveolar epithelial cells in vitro and in vivo, suggesting these cells may serve as an intracellular niche for dissemination and latency.

Elevation-dependent patterns of snow-gum dieback are moderated by trait differences between montane and subalpine forests.

The paper examines elevation-dependent patterns of snow-gum dieback and finds trait differences between montane and subalpine subspecies influence borer-damage severity.

Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity

The paper investigates how monocyte differentiation in adult skin leads to Langerhans cell identity through intrinsic and extrinsic factors.

Ancient genomic linkage couples metabolism with erythroid development

This study identifies Nprl3 as a key regulator of erythroid metabolism, showing its role in coupling metabolic and developmental processes during erythropoiesis.

Machine learning to classify mutational hotspots from molecular dynamics simulations

This paper uses machine learning to classify mutational hotspots by analyzing helical distortion from molecular dynamics simulations of DNA adducts.

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

This study reports the cryo-EM structure of a TRAP transporter from Haemophilus influenzae, revealing its dimeric architecture, Na+ sites, and substrate binding site, supported by mutagenic and functional data.

Social influences on delayed gratification in New Caledonian crows and Eurasian jays

This study examines how social context affects delayed gratification in New Caledonian crows and Eurasian jays, finding species differences in reward selection under varying social conditions.

Barley cultivars shape the abundance, phenotype, genotype and gene expression of their associated microbiota by differential root exudate secretion

Stratified tissue biofabrication by rotational internal flow layer engineering

This paper introduces RIFLE, a biofabrication method that creates multi-layered tissue-like structures with microscale cell-width layers, demonstrating its ability to encapsulate high-density cells in collagen.

Temperature impacts on dengue incidence are nonlinear and mediated by climatic and socioeconomic factors

This study examines how temperature affects dengue incidence globally, finding nonlinear relationships influenced by climatic and socioeconomic factors.

Gene expression profiling reveals B cells are highly educated by the pancreatic environment during autoimmune diabetes

The paper identifies transcriptional profiles of B cell subsets in the pancreas and lymph nodes, revealing their adaptation to the diabetic environment and potential role in autoimmune diabetes.

Assessing spatial segregation of beluga whales (Delphinapterus leucas) in Western Hudson Bay estuaries

The paper examines spatial distribution of beluga whales by age class in Western Hudson Bay estuaries, finding no segregation between groups with and without calves.

Tree phylogenetic diversity supports nature's contributions to people, but is at risk from human population growth

The paper shows human population density correlates with tree phylogenetic diversity, which is more strongly linked to ecosystem goods and services than species richness alone.

Natural protection from type 1 diabetes in Non Obese Diabetic (NOD) mice is characterised by a unique pancreatic islet phenotype

The study identifies a unique pancreatic islet phenotype in naturally-protected NOD mice, characterized by increased insulin-containing islets and regulatory immune infiltrates.

Assortative mating, autistic traits, empathizing, and systemizing

The paper examines intra-couple correlations of autistic traits, empathizing, and systemizing to test assortative mating theory in autism.

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

LY-CoV555, an anti-spike antibody from a convalescent COVID-19 patient, neutralizes SARS-CoV-2 and protects non-human primates against infection.

Enhanced BCR signalling inflicts early plasmablast and germinal centre B cell death

This study shows that enhanced BCR signaling leads to early plasmablast and GC B cell death, affecting affinity maturation and B cell tolerance.

Opposing macroevolutionary and trait-mediated patterns of threat and naturalization in flowering plants

The paper examines how threat and naturalization in flowering plants are linked to traits and macroevolutionary processes, finding opposing patterns between naturalization and threat.

The fiber knob protein of human adenovirus type 49 mediates highly efficient and promiscuous infection of cancer cell lines using a novel cell entry mechanism

This paper investigates HAdV-D49's novel cell entry mechanism, showing its pseudotyped vector efficiently infects cancer cell lines lacking known adenovirus receptors.

The effect of delayed processing on ovarian tissue stored for fertility preservation

This study examines the effect of delayed processing on ovarian tissue for fertility preservation, finding that a 48-hour delay before cryopreservation does not negatively impact primordial follicle health.

Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection

The paper describes an electronic health informatics pipeline that collects longitudinal clinical data on HBsAg and HBeAg clearance in chronic HBV infection, revealing demographic and treatment-related factors associated with clearance.

Mammal extinctions and the increasing isolation of humans on the tree of life

The paper shows that mammals closely related to humans face higher extinction risks due to human impacts, threatening our evolutionary history and biodiversity.

Disease mortality in domesticated animals is predicted by host evolutionary relationships

The paper shows that the evolutionary distance between hosts predicts disease mortality in domesticated animals caused by multi-host parasites.

A Liquid Chromatography-Mass Spectrometry Method For Screening Disulfide Tethering Fragments

The paper refines an LC/MS-based method for screening covalent small-molecule binders to proteins, achieving fast and reliable screening over multiple projects.

First Indications for Long-Term Benzodiazepine and Z-drugs use in the United Kingdom

The paper estimates the scale of long-term benzodiazepine and Z-drug use in the UK using GP data and suggests a significant number of patients may benefit from withdrawal support.