Author

E. Sijbesma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2

Frequent Co-Authors

C. Ottmann· 2 shared M. R. Arkin· 2 shared A. R. Renslo· 1 shared C. Merron· 1 shared C. Wilson· 1 shared D. N. Kenanova· 1 shared E. J. Visser· 1 shared F. Centorrino· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

C. Ottmann

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2 papers

Recent·Most cited

A Systematic Approach to the Discovery of Protein-Protein Inter-action Stabilizers

D. N. Kenanova, E. J. Visser, J. M. Virta, E. Sijbesma, F. Centorrino, H. R. Vickery, M. Zhong, J. R. Neitz, L. Brunsveld, C. Ottmann, M. R. Arkin

This study uses disulfide tethering to identify small molecule stabilizers of 14-3-3{sigma} phospho-peptide interactions, finding selective and efficacious fragments for four of five client complexes.

bioRxiv · Jan 29, 2023 · PreprintBiochemistry

A Liquid Chromatography-Mass Spectrometry Method For Screening Disulfide Tethering Fragments

K. K. Hallenbeck, J. Davies, C. Merron, P. Ogden, E. Sijbesma, C. Ottmann, A. R. Renslo, C. Wilson, M. R. Arkin

The paper refines an LC/MS-based method for screening covalent small-molecule binders to proteins, achieving fast and reliable screening over multiple projects.

bioRxiv · Aug 4, 2017Biophysics