Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound
A. Hefnawy, G. Negreira, M. Jara, J. A. Cotton, I. Maes, E. D'Haenens, H. Imamura, B. Cuypers, P. Monsieurs, C. Mouchtoglou, H. De Winter, M. Berriman, M. Sanders, J. Martin, G. De Muylder, , M. A. Domagalska
This study experimentally selects resistance to a novel anti-leishmanial compound in Leishmania donovani and identifies mutations in the dynamin-1-like protein as a key mechanism of resistance.
bioRxiv · Jan 5, 2021Microbiology