M. Berriman

A drug repurposing screen for whipworms informed by comparative genomics

This paper identifies potential anti-whipworm drugs by testing approved human drugs ex vivo and in vivo, finding limited efficacy due to pharmacokinetic challenges.

Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound

This study experimentally selects resistance to a novel anti-leishmanial compound in Leishmania donovani and identifies mutations in the dynamin-1-like protein as a key mechanism of resistance.

Tumor Necrosis Factor and Schistosoma mansoni egg antigen Omega-1 shape distinct aspects of the early egg-induced granulomatous response

This study investigates how TNF and omega-1 from Schistosoma mansoni eggs influence granuloma formation in zebrafish, showing distinct roles in macrophage recruitment and granuloma enlargement.

Defining the early stages of intestinal colonisation by whipworms

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

Rora regulates activated T helper cells during inflammation

This study investigates Rora's role in CD4+ T cells during inflammation, finding it regulates lung inflammation and is controlled by IL-33 and CCL7.

Development of caecaloids to study host-pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum

This paper develops a caecal organoid model to study host-pathogen interactions, revealing immunoregulatory effects of Trichuris muris extracellular vesicles on caecal epithelium.

Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development

This study analyzes RNA-seq data from Schistosoma mansoni during intra-mammalian development, identifying genes involved in immune evasion and adaptation to oxidative stress.

Schistosoma mansoni eggs modulate the timing of granuloma formation to promote transmission

This study shows that Schistosoma mansoni eggs modulate granuloma formation timing to promote parasite transmission by evading immune response until optimal extrusion.

Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level

The paper evaluates WGA methods for Leishmania single-cell genomics, finding PicoPlex better for aneuploidy and RepliG for SNPs, and detects aneuploidy mosaicism in L. braziliensis.

Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni

This study performs a large-scale RNAi screen in Schistosoma mansoni to identify therapeutic targets, finding genes involved in neuromuscular function, tissue integrity, and parasite survival.

Genomes of intracellular Leishmania parasites directly sequenced from patients

This paper develops a method to directly sequence Leishmania genomes from clinical samples, revealing genomic differences between intracellular parasites and cultured isolates.

A library of cell-surface and secreted proteins from Schistosoma mansoni identifies early serological markers of infection

The paper identifies early serological markers of Schistosoma mansoni infection using a recombinant protein library and mouse infection time series.

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

This study shows that IL-10R signaling in immune cells is essential for controlling whipworm infection, microbiota homeostasis, and preventing immunopathology in mice.

Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria

The paper sequenced genomes of all known Laverania Plasmodium species to understand evolutionary mechanisms and identify features enabling P. falciparum's virulence in humans.