J. A. Cotton

Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation

This study shows that PD1/PDL-1 inhibition increases IFN-γ production in VL patients, suggesting potential for immune checkpoint therapy.

Immunological factors, but not clinical features, predict visceral leishmaniasis relapse in patients co-infected with HIV

The paper identifies three immunological markers that predict visceral leishmaniasis relapse in HIV co-infected patients, showing they are more predictive than clinical features.

Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound

This study experimentally selects resistance to a novel anti-leishmanial compound in Leishmania donovani and identifies mutations in the dynamin-1-like protein as a key mechanism of resistance.

Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level

The paper evaluates WGA methods for Leishmania single-cell genomics, finding PicoPlex better for aneuploidy and RepliG for SNPs, and detects aneuploidy mosaicism in L. braziliensis.

The Phlebotomus papatasi transcriptomic response to trypanosomatid-contaminated blood is robust but non-specific

The paper examines the transcriptomic response of sand flies to trypanosomatid-contaminated blood, finding a generalized response to blood meals rather than specific parasite-related changes.

Genomes of intracellular Leishmania parasites directly sequenced from patients

This paper develops a method to directly sequence Leishmania genomes from clinical samples, revealing genomic differences between intracellular parasites and cultured isolates.

Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania

This paper compares the genome and transcriptome of the monoxenous trypanosomatid Herpetomonas muscarum with the dixenous parasite Leishmania during insect infection, finding conserved features in host interaction.