M. Sanders

Single-cell transcriptomic analysis of NK cell dynamics in myeloma patients reveal persistent reduction of cytotoxic NK cells from diagnosis to relapse

Parasite hybridization promotes spreading of endosymbiotic viruses

This study shows that parasite hybridization in cutaneous leishmaniasis increases the spread of endosymbiotic viruses, contributing to disease severity.

Robust biomarker discovery through multiplatform multiplex image analysis of breast cancer clinical cohorts

The paper identifies prognostic spatial biomarkers in breast cancer by analyzing multiple clinical cohorts using three multiplex imaging technologies.

Detecting sources of immune activation and viral rebound in HIV infection

The paper compares assays for detecting HIV-producing cells and p24 during ART to identify sources of immune activation and viral rebound.

The Forget-Me-Not dHCP study: 7 Tesla high resolution diffusion imaging in the unfixed post-mortem neonatal brain

The paper describes the Forget-Me-Not dHCP study, which acquires high-resolution diffusion MRI data from unfixed post-mortem neonatal brains and presents preliminary analyses of cortical and white matter structures.

Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound

This study experimentally selects resistance to a novel anti-leishmanial compound in Leishmania donovani and identifies mutations in the dynamin-1-like protein as a key mechanism of resistance.

Defining the early stages of intestinal colonisation by whipworms

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development

This study analyzes RNA-seq data from Schistosoma mansoni during intra-mammalian development, identifying genes involved in immune evasion and adaptation to oxidative stress.

Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level

The paper evaluates WGA methods for Leishmania single-cell genomics, finding PicoPlex better for aneuploidy and RepliG for SNPs, and detects aneuploidy mosaicism in L. braziliensis.

The Phlebotomus papatasi transcriptomic response to trypanosomatid-contaminated blood is robust but non-specific

The paper examines the transcriptomic response of sand flies to trypanosomatid-contaminated blood, finding a generalized response to blood meals rather than specific parasite-related changes.

Genomes of intracellular Leishmania parasites directly sequenced from patients

This paper develops a method to directly sequence Leishmania genomes from clinical samples, revealing genomic differences between intracellular parasites and cultured isolates.

Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria

The paper sequenced genomes of all known Laverania Plasmodium species to understand evolutionary mechanisms and identify features enabling P. falciparum's virulence in humans.