Author

C. Mycroft-West

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Yates· 5 shared M. Guerrini· 5 shared D. Fernig· 4 shared J. Turnbull· 4 shared M. Lima· 4 shared M. Skidmore· 4 shared P. Procter· 4 shared S. Guimond· 4 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

E. Yates

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Author profile →

5 papers

Recent·Most cited

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain.

C. Mycroft-West, D. Su, Y. Li, S. Guimond, T. Rudd, S. Elli, G. Miller, Q. Nunes, P. Procter, A. Bisio, N. Forsyth, J. Turnbull, M. Guerrini, D. Fernig, E. Yates, , M. Skidmore

This study shows that various glycosaminoglycans, beyond heparin, can induce conformational changes in the SARS-CoV-2 Spike S1 receptor binding domain.

bioRxiv · Apr 29, 2020 · PreprintBiochemistry

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins.

C. Mycroft-West, D. Su, Y. Li, S. Guimond, T. Rudd, S. Elli, G. Miller, Q. Nunes, P. Procter, A. Bisio, N. Forsyth, J. Turnbull, M. Guerrini, D. Fernig, E. Yates, , M. Skidmore

This study shows low molecular weight heparins induce conformational changes in SARS-CoV-2 Spike RBD, suggesting potential for repurposing as antiviral agents.

bioRxiv · Apr 29, 2020 · PreprintBiochemistry

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin.

C. Mycroft-West, D. Su, I. Pagani, T. Rudd, S. Elli, S. Guimond, G. Miller, M. Meneghetti, H. Nader, Y. Li, Q. Nunes, P. Procter, N. Mancini, M. Clementi, A. Bisio, , M. A. Skidmore

This study shows heparin inhibits SARS-CoV-2 invasion by binding to the Spike protein's RBD and inducing conformational changes, with structural features of heparin playing a key role.

bioRxiv · Apr 28, 2020Biochemistry

Analysis of solid-state heparin samples by ATR-FTIR spectroscopy

A. Devlin, C. Mycroft-West, J. Turnbull, M. Guerrini, E. Yates, M. Skidmore

This paper proposes using ATR-FTIR spectroscopy with multivariate analysis to rapidly and cost-effectively monitor heparin purity and detect contaminants.

bioRxiv · Sep 19, 2019 · PreprintBiochemistry

A glycosaminoglycan extract from Portunus pelagicus inhibits BACE1, the β secretase implicated in Alzheimer’s disease

C. Mycroft-West, L. Cooper, A. Devlin, P. Procter, S. Guimond, M. Guerrini, D. Fernig, M. Lima, E. Yates, M. Skidmore

This study identifies a marine-derived glycosaminoglycan extract from Portunus pelagicus that inhibits BACE1 with reduced anticoagulant activity compared to mammalian heparin.

bioRxiv · Apr 18, 2019Biochemistry