Author

E. Yates

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

C. Mycroft-West· 5 shared D. Fernig· 5 shared M. Guerrini· 5 shared M. Lima· 5 shared J. Turnbull· 4 shared M. Skidmore· 4 shared P. Procter· 4 shared S. Guimond· 4 shared

Activity by Year

2018-2020 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

C. Mycroft-West

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway

Z. wang, z. Cheng, S. Abrams, z. Lin, E. yates, q. Yu, w. Yu, P. Chen, C.-H. Toh, G. Wang

This study shows extracellular histones stimulate collagen production in liver fibrosis via TLR4-MyD88 signaling, and NAHP reduces fibrosis by neutralizing histones.

bioRxiv · Sep 17, 2020Pathology

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain.

C. Mycroft-West, D. Su, Y. Li, S. Guimond, T. Rudd, S. Elli, G. Miller, Q. Nunes, P. Procter, A. Bisio, N. Forsyth, J. Turnbull, M. Guerrini, D. Fernig, E. Yates, , M. Skidmore

This study shows that various glycosaminoglycans, beyond heparin, can induce conformational changes in the SARS-CoV-2 Spike S1 receptor binding domain.

bioRxiv · Apr 29, 2020 · PreprintBiochemistry

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins.

C. Mycroft-West, D. Su, Y. Li, S. Guimond, T. Rudd, S. Elli, G. Miller, Q. Nunes, P. Procter, A. Bisio, N. Forsyth, J. Turnbull, M. Guerrini, D. Fernig, E. Yates, , M. Skidmore

This study shows low molecular weight heparins induce conformational changes in SARS-CoV-2 Spike RBD, suggesting potential for repurposing as antiviral agents.

bioRxiv · Apr 29, 2020 · PreprintBiochemistry

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin.

C. Mycroft-West, D. Su, I. Pagani, T. Rudd, S. Elli, S. Guimond, G. Miller, M. Meneghetti, H. Nader, Y. Li, Q. Nunes, P. Procter, N. Mancini, M. Clementi, A. Bisio, , M. A. Skidmore

This study shows heparin inhibits SARS-CoV-2 invasion by binding to the Spike protein's RBD and inducing conformational changes, with structural features of heparin playing a key role.

bioRxiv · Apr 28, 2020Biochemistry

Heparan sulfate structure is influenced by the ER-Golgi dynamics of its modifying enzymes

M. Meneghetti, P. Deboni, C. Palomino, L. Braga, R. Cavalheiro, G. Viana, E. Yates, H. Nader, M. Lima

This study shows that changes in the localization of HS-modifying enzymes in the ER-Golgi pathway influence HS structure, highlighting the role of vesicular trafficking in HS biosynthesis.

bioRxiv · Jan 23, 2020 · PreprintCell Biology

Analysis of solid-state heparin samples by ATR-FTIR spectroscopy

A. Devlin, C. Mycroft-West, J. Turnbull, M. Guerrini, E. Yates, M. Skidmore

This paper proposes using ATR-FTIR spectroscopy with multivariate analysis to rapidly and cost-effectively monitor heparin purity and detect contaminants.

bioRxiv · Sep 19, 2019 · PreprintBiochemistry

A glycosaminoglycan extract from Portunus pelagicus inhibits BACE1, the β secretase implicated in Alzheimer’s disease

C. Mycroft-West, L. Cooper, A. Devlin, P. Procter, S. Guimond, M. Guerrini, D. Fernig, M. Lima, E. Yates, M. Skidmore

This study identifies a marine-derived glycosaminoglycan extract from Portunus pelagicus that inhibits BACE1 with reduced anticoagulant activity compared to mammalian heparin.

bioRxiv · Apr 18, 2019Biochemistry

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

D. P. Byrne, Y. Li, K. Ramakrishnan, I. Barsukov, E. Yates, C. Eyers, D. Papy-Garcia, S. Chantepie, V. Pagadala, J. Liu, C. Wells, D. Drewry, W. Zuercher, N. Berry, D. Fernig, P. A. Eyers

This paper introduces a new non-radioactive assay for HS2ST activity using a synthetic fluorescent substrate and identifies protein kinase inhibitors that inhibit HS2ST-catalyzed sulphation.

bioRxiv · Apr 6, 2018Biochemistry