Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states
K. P. Simeonov, C. N. Byrns, M. L. Clark, R. J. Norgard, B. Martin, B. Z. Stanger, A. McKenna, J. Shendure, C. J. Lengner
This study uses macsGESTALT to trace metastatic cancer lineage and transcriptomes, revealing that late-hybrid EMT states drive metastasis and are linked to poor survival in human pancreatic cancer.
bioRxiv · Aug 11, 2020Cancer Biology