Author

M. L. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. E. Baxter· 1 shared A. McKenna· 1 shared B. Martin· 1 shared B. Z. Stanger· 1 shared C. J. Lengner· 1 shared C. N. Byrns· 1 shared E. Freilich· 1 shared E. J. Wherry· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. E. Baxter

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

J. E. Wu, S. Manne, S. F. Ngiow, A. E. Baxter, H. Huang, E. Freilich, M. L. Clark, J. H. Lee, Z. Chen, O. Khan, R. P. Staupe, Y. J. Huang, J. Shi, J. R. Giles, E. J. Wherry

The paper establishes an in vitro model of CD8 T cell exhaustion and uses CRISPR screening to identify BHLHE40 as a regulator of T cell exhaustion differentiation.

bioRxiv · Apr 17, 2023 · PreprintImmunology

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states

K. P. Simeonov, C. N. Byrns, M. L. Clark, R. J. Norgard, B. Martin, B. Z. Stanger, A. McKenna, J. Shendure, C. J. Lengner

This study uses macsGESTALT to trace metastatic cancer lineage and transcriptomes, revealing that late-hybrid EMT states drive metastasis and are linked to poor survival in human pancreatic cancer.

bioRxiv · Aug 11, 2020Cancer Biology