Author

K. P. Simeonov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

A. McKenna· 1 shared B. Martin· 1 shared B. Stanger· 1 shared B. Z. Stanger· 1 shared C. J. Lengner· 1 shared C. N. Byrns· 1 shared H. Cure· 1 shared J. Shendure· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. McKenna

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2 papers

Recent·Most cited

Rapid in vivo multiplexed editing (RIME) of the adult mouse liver

T. Katsuda, H. Cure, K. P. Simeonov, Z. Arany, M. Grompe, B. Stanger

This paper introduces RIME, a method for rapid in vivo gene editing in adult mouse liver, demonstrating efficient knockout of multiple genes.

bioRxiv · Mar 4, 2022Physiology

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states

K. P. Simeonov, C. N. Byrns, M. L. Clark, R. J. Norgard, B. Martin, B. Z. Stanger, A. McKenna, J. Shendure, C. J. Lengner

This study uses macsGESTALT to trace metastatic cancer lineage and transcriptomes, revealing that late-hybrid EMT states drive metastasis and are linked to poor survival in human pancreatic cancer.

bioRxiv · Aug 11, 2020Cancer Biology