Author

B. Z. Stanger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

C. J. Lengner· 3 shared A. Thomas-Tikhonenko· 2 shared J. Li· 2 shared J. Zhang· 2 shared P. Sehgal· 2 shared X. Wang· 2 shared A. Dahal· 1 shared A. J. Merrell· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

C. J. Lengner

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Author profile →

7 papers

Recent·Most cited

Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells

T. Katsuda, J. Li, A. J. Merrell, J. Sussman, J. Matsuzaki, T. Ochiya, B. Z. Stanger

This study shows adult hepatocytes and biliary epithelial cells can proliferate extensively in vitro and differentiate into hepatocyte-like cells, supporting their use in liver regenerative medicine.

bioRxiv · Jan 3, 2023 · PreprintCell Biology

A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreas cancer

B. A. Brown, P. J. Myers, S. J. Adair, J. R. Pitarresi, S. K. Sah-Teli, L. A. Campbell, W. S. Hart, M. Barbeau, K. Leong, N. Seyler, W. Kane, K. E. Lee, E. Stelow, M. Jones, M. C. Simon, , M. J. Lazzara

This study identifies a hypoxia-driven histone methylation-MAPK feedback loop that sustains EMT in pancreatic cancer, with potential therapeutic implications.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

N. Li, Q. Zhu, Y. Tian, K. J. Ahn, X. Wang, Z. Cramer, I. W. Folkert, P. Yu, J. Jou, S. Adams-Tzivelekidis, P. Sehgal, N. N. Mahmoud, C. B. Aarons, R. E. Roses, A. Thomas-Tikhonenko, , C. J. Lengner

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

bioRxiv · Sep 13, 2022Cancer Biology

MYC hyperactivates WNT signaling in APC/CTNNB1-mutated colorectal cancer cells through miR-92a-dependent repression of DKK3

P. Sehgal, C. Lanauze, X. Wang, K. E. Hayer, M. Torres-Diz, Y. Sela, B. Z. Stanger, C. J. Lengner, A. Thomas-Tikhonenko

This study shows MYC enhances WNT signaling in colorectal cancer cells by repressing DKK3 via miR-92a, creating an oncogenic feedback loop.

bioRxiv · Jul 26, 2021Cancer Biology

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states

K. P. Simeonov, C. N. Byrns, M. L. Clark, R. J. Norgard, B. Martin, B. Z. Stanger, A. McKenna, J. Shendure, C. J. Lengner

This study uses macsGESTALT to trace metastatic cancer lineage and transcriptomes, revealing that late-hybrid EMT states drive metastasis and are linked to poor survival in human pancreatic cancer.

bioRxiv · Aug 11, 2020Cancer Biology

Clonal Heterogeneity Supports Mitochondrial Metabolism in Pancreatic Cancer

C. J. Halbrook, G. Thurston, A. McCarthy, B. S. Nelson, P. Sajjakulnukit, A. S. Krall, P. J. Mullen, L. Zhang, S. Batra, A. Viale, B. Z. Stanger, H. R. Cristofk, J. Zhang, M. Pasca di Magliano, C. Jorgensen, C. A. Lyssiotis

The paper identifies two metabolic subclasses in pancreatic cancer cells and shows asparagine's role in supporting proliferation under mitochondrial stress, suggesting a new therapeutic strategy.

bioRxiv · May 15, 2020 · PreprintCancer Biology

Non-classical estrogen signaling inhibits melanoma and improves response to PD-1 blockade

C. A. Natale, J. Li, J. Zhang, A. Dahal, B. Z. Stanger, T. W. Ridky

This study shows that GPER activation inhibits melanoma growth and enhances response to PD-1 blockade by promoting differentiation and reducing immune suppressive proteins.

bioRxiv · Jun 6, 2017Cancer Biology