Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type-1 diabetes
H. Kim, J. Perovanovic, A. Shakya, Z. Shen, C. N. German, A. Ibarra, J. L. Jafek, N.-P. Lin, B. D. Evavold, D. H.- C. Chou, P. E. Jensen, X. He, D. Tantin
This study shows that deleting or inhibiting OCA-B in T cells protects mice from type-1 diabetes by reducing autoreactive CD8+ T cells and inducing anergy in CD4+ T cells.
bioRxiv · Feb 6, 2020Immunology