Author

A. Shakya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Dubrovskiy· 1 shared A. Ibarra· 1 shared A. Local· 1 shared B. D. Evavold· 1 shared C. E. Schwartz· 1 shared C. N. German· 1 shared D. H.- C. Chou· 1 shared D. Tantin· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. Dubrovskiy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Protein unfolding thermodynamics predict multicomponent phase behavior

N. Rana, R. Kodirov, A. Shakya, J. T. King

This paper shows that protein unfolding thermodynamics can predict multicomponent phase behavior, distinguishing between liquid-like condensates and pathological aggregates.

bioRxiv · May 26, 2023 · PreprintBiophysics

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.

S. A. Saenz, A. Local, T. Carr, A. Shakya, S. Koul, H. Hu, L. Chourb, J. Stedman, J. Malley, L. A. DAgostino, V. Shanmugasundaram, J. Malona, C. E. Schwartz, L. Beebe, M. Clements, , J. M. Ellis

The paper develops three RORγt inhibitors that reduce Th17 differentiation and inflammation in vivo and inhibit tumor growth in PDAC organoids.

bioRxiv · Feb 19, 2021 · PreprintImmunology

Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type-1 diabetes

H. Kim, J. Perovanovic, A. Shakya, Z. Shen, C. N. German, A. Ibarra, J. L. Jafek, N.-P. Lin, B. D. Evavold, D. H.- C. Chou, P. E. Jensen, X. He, D. Tantin

This study shows that deleting or inhibiting OCA-B in T cells protects mice from type-1 diabetes by reducing autoreactive CD8+ T cells and inducing anergy in CD4+ T cells.

bioRxiv · Feb 6, 2020Immunology