Author

J. L. Jafek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. Ibarra· 1 shared A. Shakya· 1 shared B. D. Evavold· 1 shared C. N. German· 1 shared D. H.- C. Chou· 1 shared D. Tantin· 1 shared H. Kim· 1 shared J. Perovanovic· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

A. Ibarra

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1 paper

Recent·Most cited

Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type-1 diabetes

H. Kim, J. Perovanovic, A. Shakya, Z. Shen, C. N. German, A. Ibarra, J. L. Jafek, N.-P. Lin, B. D. Evavold, D. H.- C. Chou, P. E. Jensen, X. He, D. Tantin

This study shows that deleting or inhibiting OCA-B in T cells protects mice from type-1 diabetes by reducing autoreactive CD8+ T cells and inducing anergy in CD4+ T cells.

bioRxiv · Feb 6, 2020Immunology