Anti-PD-1/PD-L1 Therapy Triggers Cognitive Deficits and Anxiety-Like Behaviors Through Tumor-Initiated Neuroinflammatory Niches in Male Mice
C. Nicola, Martin Pédard, Martine Dubois, Laurence Desrues, Pauline Neveu, Gaëtan Riou, Ian Johnston, Paul Dembele Kleouforo, Pamela Lecras, David Vaudry, Sahil Adriouch, Florence Joly, Pascal Hilber, Olivier Wurtz, Hélène Castel
This study shows that anti-PD-1/PD-L1 therapy in mice with cancer causes cognitive deficits and anxiety through neuroinflammatory processes triggered by tumor-associated immune changes.
bioRxiv · Sep 3, 2025 · PreprintCancer Biology